Loved to Death
art by Jack Kamen, story by Al Feldstein
Tales From the Crypt #25[#9] (1951)
This is a goofy little story about Edward, a bit of a loser who is having no luck getting the girl of his dreams, Margie, interested in him. He gets referred to an alchemist, who offers to sell him a love potion for just one dollar. The alchemist also tells Edward that he expects Edward back for the antidote soon enough. For some reason this comment doesn't set off alarm bells in Edward's head. The potion works, but soon enough Edward finds himself smothered by Margie's constant adoring attention, and returns for the antidote, which turns out to be an undetectable poison which sells for one thousand dollars. Quite a scam this guy has running. Edward goes along with it, but mistakenly poisons himself. In the afterlife he's still happy to be free of the constant attention of a sexy Kamen-drawn woman, only to be shocked when Margie appears, not being willing to keep living without him.
Like I said, goofy, but some clever unexpected twists. Kamen's artwork definitely makes it stand out, though.