The basic story here is that a writer named Meru is investigating a flight from several years ago where all the passengers and crew lost their memories. The trail leads her to similar occurrences, and eventually into a massive secret world of paranormal activity and conspiracies that she may have been involved in all along. I look forward to reading the future issues and seeing if any of this resolves in a satisfactory way (and sprawling stories of conspiracies and secret organizations do have a history of not paying off, which having LOST co-creator Damon Lindelof writing the introduction kind of underscores). I'll also have to try some of Kindt's other comics.
It's also one of the best designed books I've seen in a while, which is very nice compared to the cookie-cutter, one-size-fits-all school that applies to most modern comic book collections. You get the feeling that every aspect here was carefully considered, and it doesn't look like any other book.